Full Publication List
2023
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Muta Y, Linares JF, Martinez-Ordoñez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, Garcia-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J. Nat Commun 14, 8075 (2023). https://doi.org/10.1038/s41467-023-43690-5. PMID: 38092754
THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. Omatsu M, Nakanishi Y, Iwane K, Aoyama N, Duran A, Muta Y, Martinez-Ordoñez A, Han Q, Agatsuma N, Mizukoshi K, Kawai M, Yamakawa G, Namikawa M, Hamada K, Fukunaga Y, Utsumi T, Sono M, Masuda T, Hata A, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Tsuda M, Maruno T, Kogame T, Kasashima H, Kakiuchi N, Nakagawa MM, Kawada K, Yashiro M, Maeda K, Saito Y, Matozaki T, Fukuda A, Kabashima K, Obama K, Ogawa S, Sheibani N, Diaz-Meco MT, Moscat J, Seno H. Nat Commun. 2023 Sep 25;14(1):5534. doi: 10.1038/s41467-023-41095-y. PMID: 37749092
Sessile serrated lesions with dysplasia: is it possible to nip them in the bud? Utsumi T, Yamada Y, Diaz-Meco MT, Moscat J, Nakanishi Y. J Gastroenterol. 2023 Aug;58(8):705-717. doi: 10.1007/s00535-023-02003-9. Epub 2023 May 23. PMID: 37219625. Review.
Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures. Martinez-Ordoñez A, Cid-Diaz T, Duran A, Han Q, Moscat J, Diaz-Meco MT.STAR Protoc. 2023 Apr 20;4(2):102243. doi: 10.1016/j.xpro.2023.102243. Online ahead of print.PMID: 37083323
Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer. Martinez-Ordoñez A, Duran A, Ruiz-Martinez M, Cid-Diaz T, Zhang X, Han Q, Kinoshita H, Muta Y, Linares JF, Kasashima H, Nakanishi Y, Omar M, Nishimura S, Avila L, Yashiro M, Maeda K, Pannellini T, Pigazzi A, Inghirami G, Marchionni L, Sigal D, Diaz-Meco MT, Moscat J. Cancer Cell. 2023 Feb 13;41(2):252-271.e9. doi: 10.1016/j.ccell.2022.11.016. Epub 2022 Dec 15. PMID: 36525970.
2022
Air-liquid organotypic assays to investigate cellular crosstalk in the tumor microenvironment of cancer cells. Cid-Diaz T, Lodeiro AC, Duran A, Moscat J, Diaz-Meco MT.STAR Protoc. 2022 Aug 18;3(3):101635. doi: 10.1016/j.xpro.2022.101635. eCollection 2022 Sep 16.PMID: 36035805
The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62. Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo HH, Elemento O, Martin ML, Cordes T, Thompson TC, Metallo CM, Moscat J, Diaz-Meco MT. Cell Rep. Cell Rep. 2022 May 10; 39(6): 110792. doi: 10.1016/j.celrep.2022.110792. PMCID: PMC9136538
Protein kinase Cλ/ι in cancer: a contextual balance of time and signals. Moscat J, Linares JF, Duran A, Diaz-Meco MT. Trends Cell Biol. 2022 April 29, S0962-8924(22)00090-3. doi: 10.1016/j.tcb.2022.04.002. Online ahead of print. PMID: 35501226 Review.
Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm. Moscat J, Cuervo AM, Diaz-Meco MT.Autophagy. 2022 Jan;18(1):226-227. doi: 10.1080/15548627.2021.1991192. Epub 2021 Dec 12.PMID: 34895031
2021
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. Linares JF, Zhang X, Martinez-Ordoñez A, Duran A, Kinoshita H, Kasashima H, Nakanishi N, Nakanishi Y, Carelli R, Cappelli L, Arias E, Yashiro M, Ohira M, Patel S, Inghirami G, Loda M, Cuervo AM, Diaz-Meco MT, Moscat J. Molecular Cell. 2021 November 4, 81, 1–18. doi.org/10.1016/j.molcel.2021.08.039ll
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ. Huang J, Linares JF, Duran A, Xia W, Saltiel AR, Müller TD, Diaz-Meco MT, Moscat J. Nat Commun. 2021 May 17;12(1):2876. doi: 10.1038/s41467-021-23085-0. PMID: 34001883
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. Cancer Cell. 2021 May 10;39(5):678-693.e11. doi: 10.1016/j.ccell.2021.02.016. Epub 2021 Mar 18. PMID: 33740421
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Klionsky DJ et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751
Mouse model of colorectal cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum. Kasashima H, Duran A, Cid-Diaz T, Muta Y, Kinoshita H, Batlle E, Diaz-Meco MT, Moscat J.STAR Protoc. 2021 Jan 22;2(1):100297. doi: 10.1016/j.xpro.2021.100297. eCollection 2021 Mar 19. PMID: 33554135. Free PMC article.
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population. Kasashima H, Duran A, Martinez-Ordoñez A, Nakanishi Y, Kinoshita H, Linares JF, Reina-Campos M, Kudo Y, L'Hermitte A, Yashiro M, Ohira M, Bao F, Tauriello DVF, Batlle E, Diaz-Meco MT, Moscat J. Dev Cell. 2021 Jan 11;56(1):95-110.e10. doi: 10.1016/j.devcel.2020.10.014. Epub 2020 Nov 17. PMID: 33207226
2020
Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Althoff MJ, Nayak RC, Hegde S, Wellendorf AM, Bohan B, Filippi MD, Xin M, Lu QR, Geiger H, Zheng Y, Diaz-Meco MT, Moscat J, Cancelas JA. Blood. 2020 Oct 15;136(16):1824-1836. doi: 10.1182/blood.2019004113. PMID: 32483624
Fructose stimulated de novo lipogenesis is promoted by inflammation. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. Nat Metab. 2020 Oct;2(10):1034-1045. doi: 10.1038/s42255-020-0261-2. Epub 2020 Aug 24. PMID: 32839596
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. Cancer Cell. 2020 Aug 10;38(2):247-262.e11. doi: 10.1016/j.ccell.2020.05.018. Epub 2020 Jun 25. PMID: 32589943
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Fischer K, Fenzl A, Liu D, Dyar KA, Kleinert M, Brielmeier M, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Huang J, Keipert S, Klingenspor M, Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD. Nat Commun. 2020 May 8;11(1):2306. doi: 10.1038/s41467-020-16230-8. PMID: 32385399 Free PMC article.
The complexity of the serine glycine one-carbon pathway in cancer. Reina-Campos M, Diaz-Meco MT, Moscat J J Cell Biol. 2020 Jan 6;219(1):e201907022. doi: 10.1083/jcb.201907022. PMID: 31690618 Free PMC article. Review.
2019
Serrated Colorectal Cancer: The Road Less Travelled? Nakanishi Y, Diaz-Meco MT, Moscat J. Trends Cancer. 2019 Nov;5(11):742-754. doi: 10.1016/j.trecan.2019.09.004. Epub 2019 Oct 28. PMID: 31735291 Free PMC article. Review.
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer. Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K, Beltran H, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT. Cancer Cell. 2019 Mar 18;35(3):385-400.e9. doi: 10.1016/j.ccell.2019.01.018. Epub 2019 Feb 28. PMID: 30827887 Free PMC article.
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors. Nayak RC, Hegde S, Althoff MJ, Wellendorf AM, Mohmoud F, Perentesis J, Reina-Campos M, Reynaud D, Zheng Y, Diaz-Meco MT, Moscat J, Cancelas JA. Nat Commun. 2019 Jan 4;10(1):46. doi: 10.1038/s41467-018-07846-y. PMID: 30610188 Free PMC article.
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Karras P, Riveiro-Falkenbach E, Cañón E, Tejedo C, Calvo TG, Martínez-Herranz R, Alonso-Curbelo D, Cifdaloz M, Perez-Guijarro E, Gómez-López G, Ximenez-Embun P, Muñoz J, Megias D, Olmeda D, Moscat J, Ortiz-Romero PL, Rodríguez-Peralto JL, Soengas MS. Cancer Cell. 2019 Jan 14;35(1):46-63.e10. doi: 10.1016/j.ccell.2018.11.008. Epub 2018 Dec 20. PMID: 30581152
2018
Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J. Immunity. 2018 Dec 18;49(6):1132-1147.e7. doi: 10.1016/j.immuni.2018.09.013. Epub 2018 Dec 11. PMID: 30552022 Free PMC article.
ZZ-dependent regulation of p62/SQSTM1 in autophagy. Zhang Y, Mun SR, Linares JF, Ahn J, Towers CG, Ji CH, Fitzwalter BE, Holden MR, Mi W, Shi X, Moscat J, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG. Nat Commun. 2018 Oct 22;9(1):4373. doi: 10.1038/s41467-018-06878-8. PMID: 30349045 Free PMC article.
Metabolic reprogramming of the tumor microenvironment by p62 and its partners. Reina-Campos M, Shelton PM, Diaz-Meco MT, Moscat J. Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):88-95. doi: 10.1016/j.bbcan.2018.04.010. Epub 2018 Apr 25. PMID: 29702207 Free PMC article. Review.
The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer. Shelton PM, Duran A, Nakanishi Y, Reina-Campos M, Kasashima H, Llado V, Ma L, Campos A, García-Olmo D, García-Arranz M, García-Olmo DC, Olmedillas-López S, Caceres JF, Diaz-Meco MT, Moscat J. Cell Rep. 2018 Apr 24;23(4):1178-1191. doi: 10.1016/j.celrep.2018.03.118. PMID: 29694894 Free PMC article.
Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor. Huang J, Duran A, Reina-Campos M, Valencia T, Castilla EA, Müller TD, Tschöp MH, Moscat J, Diaz-Meco MT. Cancer Cell. 2018 Apr 9;33(4):770-784.e6. doi: 10.1016/j.ccell.2018.03.001. PMID: 29634950 Free PMC article.
The macroenviromental control of cancer metabolism by p62. Huang J, Diaz-Meco MT, Moscat J. Cell Cycle. 2018;17(17):2110-2121. doi: 10.1080/15384101.2018.1520566. Epub 2018 Sep 20. PMID: 30198373 Free PMC article. Review.
2017
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Cancer Cell. 2017 Dec 11;32(6):824-839.e8. doi: 10.1016/j.ccell.2017.10.011. Epub 2017 Nov 16. PMID: 29153842 Free PMC article.
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PMID: 28988820 Free PMC article.
Correction for Linares et al., "Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation". Linares JF, Amanchy R, Greis K, Diaz-Meco MT, Moscat J. Mol Cell Biol. 2017 Jul 14;37(15):e00252-17. doi: 10.1128/MCB.00252-17. Print 2017 Aug 1. PMID: 28710122 Free PMC article. No abstract available.
Metabolism shapes the tumor microenvironment. Reina-Campos M, Moscat J, Diaz-Meco M. Curr Opin Cell Biol. 2017 Oct;48:47-53. doi: 10.1016/j.ceb.2017.05.006. Epub 2017 Jun 9. PMID: 28605656 Free PMC article. Review.
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Lam HC, Baglini CV, Lope AL, Parkhitko AA, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh J, Kavanagh T, Handen A, Chan SY, Asara JM, Oldham WM, Diaz-Meco MT, Moscat J, Sahin M, Priolo C, Henske EP. Cancer Res. 2017 Jun 15;77(12):3255-3267. doi: 10.1158/0008-5472.CAN-16-2458. Epub 2017 May 16. PMID: 28512249 Free PMC article.
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. Hu M, Luo Q, Alitongbieke G, Chong S, Xu C, Xie L, Chen X, Zhang D, Zhou Y, Wang Z, Ye X, Cai L, Zhang F, Chen H, Jiang F, Fang H, Yang S, Liu J, Diaz-Meco MT, Su Y, Zhou H, Moscat J, Lin X, Zhang XK. Mol Cell. 2017 Apr 6;66(1):141-153.e6. doi: 10.1016/j.molcel.2017.03.008. PMID: 28388439 Free PMC article.
2016
p62 in Cancer: Signaling Adaptor Beyond Autophagy. Moscat J, Karin M, Diaz-Meco MT. Cell. 2016 Oct 20;167(3):606-609. doi: 10.1016/j.cell.2016.09.030. PMID: 27768885 Free PMC article. Review.
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. Cancer Cell. 2016 Oct 10;30(4):595-609. doi: 10.1016/j.ccell.2016.09.004. PMID: 27728806 Free PMC article.
miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3. Zhou Y, Dang J, Chang KY, Yau E, Aza-Blanc P, Moscat J, Rana TM. Cancer Res. 2016 Oct 1;76(19):5777-5787. doi: 10.1158/0008-5472.CAN-15-2936. PMID: 27698189 Free PMC article.
Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι. Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J. Cell Rep. 2016 Sep 20;16(12):3297-3310. doi: 10.1016/j.celrep.2016.08.054. PMID: 27653691 Free PMC article.
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. Cancer Cell. 2016 Jun 13;29(6):935-948. doi: 10.1016/j.ccell.2016.04.006. Epub 2016 May 19. PMID: 27211490 Free PMC article.
Nuclear fallout provides a new link between aPKC and polarized cell trafficking. Calero-Cuenca FJ, Espinosa-Vázquez JM, Reina-Campos M, Díaz-Meco MT, Moscat J, Sotillos S. BMC Biol. 2016 Apr 18;14:32. doi: 10.1186/s12915-016-0253-6. PMID: 27089924 Free PMC article.
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, Zong WX. Mol Cell. 2016 Apr 7;62(1):149-51. doi: 10.1016/j.molcel.2016.03.015. PMID: 27058791 No abstract available.
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Pan JA, Sun Y, Jiang YP, Bott AJ, Jaber N, Dou Z, Yang B, Chen JS, Catanzaro JM, Du C, Ding WX, Diaz-Meco MT, Moscat J, Ozato K, Lin RZ, Zong WX. Mol Cell. 2016 Mar 3;61(5):720-733. doi: 10.1016/j.molcel.2016.02.007. PMID: 26942676 Free PMC article.
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057. PMID: 26919428 Free PMC article.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky DJ, Abdelmohsen K, Abe A, et al. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. PMID: 26799652 Free PMC article. No abstract available.
2015
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade. Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J, Diaz-Meco MT. Cell Rep. 2015 Aug 25;12(8):1339-52. doi: 10.1016/j.celrep.2015.07.045. Epub 2015 Aug 13. PMID: 26279575 Free PMC article.
Nutrient stress revamps cancer cell metabolism. Moscat J, Richardson A, Diaz-Meco MT. Cell Res. 2015 May;25(5):537-8. doi: 10.1038/cr.2015.38. Epub 2015 Mar 31. PMID: 25828529 Free PMC article.
Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Llado V, Nakanishi Y, Duran A, Reina-Campos M, Shelton PM, Linares JF, Yajima T, Campos A, Aza-Blanc P, Leitges M, Diaz-Meco MT, Moscat J. Cell Rep. 2015 Feb 10;10(5):740-754. doi: 10.1016/j.celrep.2015.01.007. Epub 2015 Feb 5. PMID: 25660024 Free PMC article.
2014
p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche. Chang KH, Sengupta A, Nayak RC, Duran A, Lee SJ, Pratt RG, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, Aronow BJ, Starczynowski DT, Civitelli R, Diaz-Meco MT, Moscat J, Cancelas JA. Cell Rep. 2014 Dec 24;9(6):2084-97. doi: 10.1016/j.celrep.2014.11.031. Epub 2014 Dec 18. PMID: 25533346 Free PMC article.
A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J. Cell Metab. 2014 Sep 2;20(3):499-511. doi: 10.1016/j.cmet.2014.06.008. Epub 2014 Jul 17. PMID: 25043814 Free PMC article.
Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. Calderilla-Barbosa L, Seibenhener ML, Du Y, Diaz-Meco MT, Moscat J, Yan J, Wooten MW, Wooten MC. J Cell Sci. 2014 Sep 15;127(Pt 18):4052-63. doi: 10.1242/jcs.152363. Epub 2014 Jul 11. PMID: 25015291 Free PMC article.
Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Valencia T, Kim JY, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco MT, Moscat J. Cancer Cell. 2014 Jul 14;26(1):121-135. doi: 10.1016/j.ccr.2014.05.004. Epub 2014 Jul 4. PMID: 25002027 Free PMC article.
2013
SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity. Yan J, Seibenhener ML, Calderilla-Barbosa L, Diaz-Meco MT, Moscat J, Jiang J, Wooten MW, Wooten MC. PLoS One. 2013 Sep 27;8(9):e76016. doi: 10.1371/journal.pone.0076016. eCollection 2013. PMID: 24086678 Free PMC article.
K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Linares JF, Duran A, Yajima T, Pasparakis M, Moscat J, Diaz-Meco MT. Mol Cell. 2013 Aug 8;51(3):283-96. doi: 10.1016/j.molcel.2013.06.020. Epub 2013 Aug 1. PMID: 23911927 Free PMC article.
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. J Clin Invest. 2013 May;123(5):2231-43. doi: 10.1172/JCI64498. Epub 2013 Apr 8. PMID: 23563314 Free PMC article.
c-Myc phosphorylation by PKCζ represses prostate tumorigenesis. Kim JY, Valencia T, Abu-Baker S, Linares J, Lee SJ, Yajima T, Chen J, Eroshkin A, Castilla EA, Brill LM, Medvedovic M, Leitges M, Moscat J, Diaz-Meco MT. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6418-23. doi: 10.1073/pnas.1221799110. Epub 2013 Apr 2. PMID: 23550155 Free PMC article.
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J. Cell. 2013 Jan 31;152(3):599-611. doi: 10.1016/j.cell.2012.12.028. PMID: 23374352 Free PMC article.
p62 links β-adrenergic input to mitochondrial function and thermogenesis. Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. J Clin Invest. 2013 Jan;123(1):469-78. doi: 10.1172/JCI64209. Epub 2012 Dec 21. PMID: 23257354 Free PMC article.
A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity. Seibenhener ML, Du Y, Diaz-Meco MT, Moscat J, Wooten MC, Wooten MW. Biochim Biophys Acta. 2013 Mar;1833(3):452-9. doi: 10.1016/j.bbamcr.2012.11.004. Epub 2012 Nov 9. PMID: 23147249 Free PMC article.
2012
Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance. Habegger KM, Matzke D, Ottaway N, Hembree J, Holland J, Raver C, Mansfeld J, Müller TD, Perez-Tilve D, Pfluger PT, Lee SJ, Diaz-Meco M, Moscat J, Leitges M, Tschöp MH, Hofmann SM. Adipocyte. 2012 Oct 1;1(4):203-214. doi: 10.4161/adip.20891. PMID: 23700535 Free PMC article.
TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor. Geetha T, Zheng C, McGregor WC, Douglas White B, Diaz-Meco MT, Moscat J, Babu JR. Neurochem Int. 2012 Dec;61(8):1289-93. doi: 10.1016/j.neuint.2012.09.005. Epub 2012 Sep 24. PMID: 23017601 Free PMC article.
Th1/Th2 Differentiation and B Cell Function by the Atypical PKCs and Their Regulators. Martin P, Moscat J. Front Immunol. 2012 Aug 6;3:241. doi: 10.3389/fimmu.2012.00241. eCollection 2012. PMID: 22888333 Free PMC article.
Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ, Abdalla FC, Abeliovich H, et al. Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496. PMID: 22966490 Free PMC article.
p62: a versatile multitasker takes on cancer. Moscat J, Diaz-Meco MT. Trends Biochem Sci. 2012 Jun;37(6):230-6. doi: 10.1016/j.tibs.2012.02.008. Epub 2012 Mar 15. PMID: 22424619 Free PMC article. Review.
The atypical PKCs in inflammation: NF-κB and beyond. Diaz-Meco MT, Moscat J. Immunol Rev. 2012 Mar;246(1):154-67. doi: 10.1111/j.1600-065X.2012.01093.x. PMID: 22435553 Free PMC article. Review.
Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. García-Hoz C, Sánchez-Fernández G, García-Escudero R, Fernández-Velasco M, Palacios-García J, Ruiz-Meana M, Díaz-Meco MT, Leitges M, Moscat J, García-Dorado D, Boscá L, Mayor F Jr, Ribas C. J Biol Chem. 2012 Mar 2;287(10):7792-802. doi: 10.1074/jbc.M111.282210. Epub 2012 Jan 9. PMID: 22232556 Free PMC article.
2011
Feedback on fat: p62-mTORC1-autophagy connections. Moscat J, Diaz-Meco MT. Cell. 2011 Nov 11;147(4):724-7. doi: 10.1016/j.cell.2011.10.021. PMID: 22078874 Free PMC article. Review.
p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT. Mol Cell. 2011 Oct 7;44(1):134-46. doi: 10.1016/j.molcel.2011.06.038. PMID: 21981924 Free PMC article.
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Sengupta A, Duran A, Ishikawa E, Florian MC, Dunn SK, Ficker AM, Leitges M, Geiger H, Diaz-Meco M, Moscat J, Cancelas JA. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9957-62. doi: 10.1073/pnas.1103132108. Epub 2011 Jun 8. PMID: 21653884 Free PMC article.
Fine tuning NF-κB: new openings for PKC-ζ. Moscat J, Diaz-Meco MT. Nat Immunol. 2011 Jan;12(1):12-4. doi: 10.1038/ni0111-12. PMID: 21169999 Free PMC article.
Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation. Linares JF, Amanchy R, Greis K, Diaz-Meco MT, Moscat J. Mol Cell Biol. 2011 Jan;31(1):105-17. doi: 10.1128/MCB.00620-10. Epub 2010 Oct 25. PMID: 20974803 Free PMC article.
2010
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo. Yang JQ, Liu H, Diaz-Meco MT, Moscat J. EMBO J. 2010 Oct 6;29(19):3421-33. doi: 10.1038/emboj.2010.214. Epub 2010 Aug 31. PMID: 20808283 Free PMC article.
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Lee SJ, Kim JY, Nogueiras R, Linares JF, Perez-Tilve D, Jung DY, Ko HJ, Hofmann SM, Drew A, Leitges M, Kim JK, Tschöp MH, Diaz-Meco MT, Moscat J. Cell Metab. 2010 Jul 7;12(1):65-77. doi: 10.1016/j.cmet.2010.05.003. PMID: 20620996 Free PMC article.
G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). García-Hoz C, Sánchez-Fernández G, Díaz-Meco MT, Moscat J, Mayor F, Ribas C. J Biol Chem. 2010 Apr 30;285(18):13480-9. doi: 10.1074/jbc.M109.098699. Epub 2010 Mar 3. PMID: 20200162 Free PMC article.
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. Lee SJ, Pfluger PT, Kim JY, Nogueiras R, Duran A, Pagès G, Pouysségur J, Tschöp MH, Diaz-Meco MT, Moscat J. EMBO Rep. 2010 Mar;11(3):226-32. doi: 10.1038/embor.2010.7. Epub 2010 Feb 12. PMID: 20154642 Free PMC article.
Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. Yao H, Hwang JW, Moscat J, Diaz-Meco MT, Leitges M, Kishore N, Li X, Rahman I. J Biol Chem. 2010 Feb 19;285(8):5405-16. doi: 10.1074/jbc.M109.041418. Epub 2009 Dec 11. PMID: 20007975 Free PMC article.
2009
Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex. Moscat J, Diaz-Meco MT, Wooten MW. Cell Death Differ. 2009 Nov;16(11):1426-37. doi: 10.1038/cdd.2009.119. Epub 2009 Aug 28. PMID: 19713972 Free PMC article. Review.
To aggregate or not to aggregate? A new role for p62. Moscat J, Diaz-Meco MT. EMBO Rep. 2009 Aug;10(8):804. doi: 10.1038/embor.2009.172. PMID: 19648954 Free PMC article. No abstract available.
p62 at the crossroads of autophagy, apoptosis, and cancer. Moscat J, Diaz-Meco MT. Cell. 2009 Jun 12;137(6):1001-4. doi: 10.1016/j.cell.2009.05.023. PMID: 19524504 Free PMC article. Review.
Nephrin deficiency activates NF-kappaB and promotes glomerular injury. Hussain S, Romio L, Saleem M, Mathieson P, Serrano M, Moscat J, Diaz-Meco M, Scambler P, Koziell A. J Am Soc Nephrol. 2009 Aug;20(8):1733-43. doi: 10.1681/ASN.2008111219. Epub 2009 Jun 4. PMID: 19497968 Free PMC article.
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma. Fernandez-Marcos PJ, Abu-Baker S, Joshi J, Galvez A, Castilla EA, Cañamero M, Collado M, Saez C, Moreno-Bueno G, Palacios J, Leitges M, Serrano M, Moscat J, Diaz-Meco MT. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12962-7. doi: 10.1073/pnas.0813055106. Epub 2009 May 26. PMID: 19470463 Free PMC article.
Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1). Trakala M, Arias CF, García MI, Moreno-Ortiz MC, Tsilingiri K, Fernández PJ, Mellado M, Díaz-Meco MT, Moscat J, Serrano M, Martínez-A C, Balomenos D. Eur J Immunol. 2009 Mar;39(3):810-9. doi: 10.1002/eji.200838676. PMID: 19224635
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo. Yang JQ, Leitges M, Duran A, Diaz-Meco MT, Moscat J. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1099-104. doi: 10.1073/pnas.0805907106. Epub 2009 Jan 14. PMID: 19144923 Free PMC article.
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Galvez AS, Duran A, Linares JF, Pathrose P, Castilla EA, Abu-Baker S, Leitges M, Diaz-Meco MT, Moscat J. Mol Cell Biol. 2009 Jan;29(1):104-15. doi: 10.1128/MCB.01294-08. Epub 2008 Oct 27. PMID: 18955501 Free PMC article.
2008
Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4. Diaz-Meco MT, Moscat J. Cell Cycle. 2008 Sep 15;7(18):2817-20. doi: 10.4161/cc.7.18.6735. Epub 2008 Sep 5. PMID: 18769154
Ouabain inhibits p38 activation in thymocytes. Rodrigues-Mascarenhas S, Bloise FF, Moscat J, Rumjanek VM. Cell Biol Int. 2008 Oct;32(10):1323-8. doi: 10.1016/j.cellbi.2008.07.012. Epub 2008 Jul 25. PMID: 18703152
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. Joshi J, Fernandez-Marcos PJ, Galvez A, Amanchy R, Linares JF, Duran A, Pathrose P, Leitges M, Cañamero M, Collado M, Salas C, Serrano M, Moscat J, Diaz-Meco MT. EMBO J. 2008 Aug 20;27(16):2181-93. doi: 10.1038/emboj.2008.149. Epub 2008 Jul 24. PMID: 18650932 Free PMC article.
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. Ramesh Babu J, Lamar Seibenhener M, Peng J, Strom AL, Kemppainen R, Cox N, Zhu H, Wooten MC, Diaz-Meco MT, Moscat J, Wooten MW. J Neurochem. 2008 Jul;106(1):107-20. doi: 10.1111/j.1471-4159.2008.05340.x. Epub 2008 Jul 1. PMID: 18346206
Polarized subcellular localization of Jak/STAT components is required for efficient signaling. Sotillos S, Díaz-Meco MT, Moscat J, Castelli-Gair Hombría J. Curr Biol. 2008 Apr 22;18(8):624-9. doi: 10.1016/j.cub.2008.03.055. PMID: 18424141
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Duran A, Linares JF, Galvez AS, Wikenheiser K, Flores JM, Diaz-Meco MT, Moscat J. Cancer Cell. 2008 Apr;13(4):343-54. doi: 10.1016/j.ccr.2008.02.001. PMID: 18394557
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. Wooten MW, Geetha T, Babu JR, Seibenhener ML, Peng J, Cox N, Diaz-Meco MT, Moscat J. J Biol Chem. 2008 Mar 14;283(11):6783-9. doi: 10.1074/jbc.M709496200. Epub 2008 Jan 3. PMID: 18174161
2007
Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Moreno-Bueno G, Fernandez-Marcos PJ, Collado M, Tendero MJ, Rodriguez-Pinilla SM, Garcia-Cao I, Hardisson D, Diaz-Meco MT, Moscat J, Serrano M, Palacios J. Cancer Res. 2007 Mar 1;67(5):1927-34. doi: 10.1158/0008-5472.CAN-06-2687. PMID: 17332319
2006
Signal integration and diversification through the p62 scaffold protein. Moscat J, Diaz-Meco MT, Wooten MW. Trends Biochem Sci. 2007 Feb;32(2):95-100. doi: 10.1016/j.tibs.2006.12.002. Epub 2006 Dec 15. PMID: 17174552 Review.
Cell signaling and function organized by PB1 domain interactions. Moscat J, Diaz-Meco MT, Albert A, Campuzano S. Mol Cell. 2006 Sep 1;23(5):631-40. doi: 10.1016/j.molcel.2006.08.002. PMID: 16949360 Review.
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. Martin P, Diaz-Meco MT, Moscat J. EMBO J. 2006 Aug 9;25(15):3524-33. doi: 10.1038/sj.emboj.7601250. Epub 2006 Jul 27. PMID: 16874300 Free PMC article.
PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways. Moscat J, Rennert P, Diaz-Meco MT. Cell Death Differ. 2006 May;13(5):702-11. doi: 10.1038/sj.cdd.4401823. PMID: 16322752 Review.
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Rodriguez A, Durán A, Selloum M, Champy MF, Diez-Guerra FJ, Flores JM, Serrano M, Auwerx J, Diaz-Meco MT, Moscat J. Cell Metab. 2006 Mar;3(3):211-22. doi: 10.1016/j.cmet.2006.01.011. PMID: 16517408
2005
The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J. J Biol Chem. 2005 Oct 21;280(42):35625-9. doi: 10.1074/jbc.C500237200. Epub 2005 Aug 3. PMID: 16079148
Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. Martin P, Villares R, Rodriguez-Mascarenhas S, Zaballos A, Leitges M, Kovac J, Sizing I, Rennert P, Márquez G, Martínez-A C, Diaz-Meco MT, Moscat J. Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9866-71. doi: 10.1073/pnas.0501202102. Epub 2005 Jun 29. PMID: 15987782 Free PMC article.
Tumour-suppression activity of the proapoptotic regulator Par4. García-Cao I, Duran A, Collado M, Carrascosa MJ, Martín-Caballero J, Flores JM, Diaz-Meco MT, Moscat J, Serrano M. EMBO Rep. 2005 Jun;6(6):577-83. doi: 10.1038/sj.embor.7400421. PMID: 15877079 Free PMC article.
Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Allemand E, Guil S, Myers M, Moscat J, Cáceres JF, Krainer AR. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3605-10. doi: 10.1073/pnas.0409889102. Epub 2005 Feb 28. PMID: 15738418 Free PMC article.
2004
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. Durán A, Rodriguez A, Martin P, Serrano M, Flores JM, Leitges M, Diaz-Meco MT, Moscat J. EMBO J. 2004 Nov 24;23(23):4595-605. doi: 10.1038/sj.emboj.7600468. Epub 2004 Nov 4. PMID: 15526032 Free PMC article.
The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling. Sole C, Dolcet X, Segura MF, Gutierrez H, Diaz-Meco MT, Gozzelino R, Sanchis D, Bayascas JR, Gallego C, Moscat J, Davies AM, Comella JX. J Cell Biol. 2004 Nov 8;167(3):479-92. doi: 10.1083/jcb.200403093. Epub 2004 Nov 1. PMID: 15520226 Free PMC article.
DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. Sotillos S, Díaz-Meco MT, Caminero E, Moscat J, Campuzano S. J Cell Biol. 2004 Aug 16;166(4):549-57. doi: 10.1083/jcb.200311031. Epub 2004 Aug 9. PMID: 15302858 Free PMC article.
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Durán A, Serrano M, Leitges M, Flores JM, Picard S, Brown JP, Moscat J, Diaz-Meco MT. Dev Cell. 2004 Feb;6(2):303-9. doi: 10.1016/s1534-5807(03)00403-9. PMID: 14960283
2003
Regulation of mature T lymphocyte proliferation and differentiation by Par-4. Lafuente MJ, Martin P, Garcia-Cao I, Diaz-Meco MT, Serrano M, Moscat J. EMBO J. 2003 Sep 15;22(18):4689-98. doi: 10.1093/emboj/cdg460. PMID: 12970181 Free PMC article.
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. Duran A, Diaz-Meco MT, Moscat J. EMBO J. 2003 Aug 1;22(15):3910-8. doi: 10.1093/emboj/cdg370. PMID: 12881425 Free PMC article.
Par-4 keeps the atypical PKCs at bay. Moscat J, Diaz-Meco MT. Cell Cycle. 2003 Mar-Apr;2(2):71-2. PMID: 12695647 No abstract available.
Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38. Garcia-Cao I, Lafuente MJ, Criado LM, Diaz-Meco MT, Serrano M, Moscat J. EMBO Rep. 2003 Mar;4(3):307-12. doi: 10.1038/sj.embor.embor769. PMID: 12634851 Free PMC article.
NF-kappaB activation by protein kinase C isoforms and B-cell function. Moscat J, Diaz-Meco MT, Rennert P. EMBO Rep. 2003 Jan;4(1):31-6. doi: 10.1038/sj.embor.embor704. PMID: 12524517 Free PMC article. Review.
2002
The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway. Avila A, Silverman N, Diaz-Meco MT, Moscat J. Mol Cell Biol. 2002 Dec;22(24):8787-95. doi: 10.1128/mcb.22.24.8787-8795.2002. PMID: 12446795 Free PMC article.
Role of zeta PKC in B-cell signaling and function. Martin P, Duran A, Minguet S, Gaspar ML, Diaz-Meco MT, Rennert P, Leitges M, Moscat J. EMBO J. 2002 Aug 1;21(15):4049-57. doi: 10.1093/emboj/cdf407. PMID: 12145205 Free PMC article.
The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies. Moscat J, Diaz-Meco MT. Adv Enzyme Regul. 2002;42:173-9. doi: 10.1016/s0065-2571(01)00029-2. PMID: 12123714 No abstract available.
OPR, PC and AID: all in the PB1 family. Ponting CP, Ito T, Moscat J, Diaz-Meco MT, Inagaki F, Sumimoto H. Trends Biochem Sci. 2002 Jan;27(1):10. doi: 10.1016/s0968-0004(01)02006-0. PMID: 11796218 No abstract available.
2001
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Leitges M, Sanz L, Martin P, Duran A, Braun U, García JF, Camacho F, Diaz-Meco MT, Rennert PD, Moscat J. Mol Cell. 2001 Oct;8(4):771-80. doi: 10.1016/s1097-2765(01)00361-6. PMID: 11684013
MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Diaz-Meco MT, Moscat J. Mol Cell Biol. 2001 Feb;21(4):1218-27. doi: 10.1128/MCB.21.4.1218-1227.2001. PMID: 11158308 Free PMC article.
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. Wooten MW, Seibenhener ML, Mamidipudi V, Diaz-Meco MT, Barker PA, Moscat J. J Biol Chem. 2001 Mar 16;276(11):7709-12. doi: 10.1074/jbc.C000869200. Epub 2001 Jan 22. PMID: 11244088
Regulation and role of the atypical PKC isoforms in cell survival during tumor transformation. Moscat J, Sanz L, Sanchez P, Diaz-Meco MT. Adv Enzyme Regul. 2001;41:99-120. doi: 10.1016/s0065-2571(00)00009-1. PMID: 11384740 No abstract available.
2000
The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. Moscat J, Diaz-Meco MT. EMBO Rep. 2000 Nov;1(5):399-403. doi: 10.1093/embo-reports/kvd098. PMID: 11258478 Free PMC article. Review.
The ins and outs of protein phosphorylation. Workshop report: control of signaling by protein phosphorylation. Thomas G, de Pablo F, Schlessinger J, Moscat J. EMBO Rep. 2000 Jul;1(1):11-5. doi: 10.1093/embo-reports/kvd014.PMID: 11256615 Free PMC article. No abstract available.
The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. Rust C, Karnitz LM, Paya CV, Moscat J, Simari RD, Gores GJ. J Biol Chem. 2000 Jun 30;275(26):20210-6. doi: 10.1074/jbc.M909992199. PMID: 10770953
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. van der Houven van Oordt W, Diaz-Meco MT, Lozano J, Krainer AR, Moscat J, Cáceres JF. J Cell Biol. 2000 Apr 17;149(2):307-16. doi: 10.1083/jcb.149.2.307. PMID: 10769024 Free PMC article.
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. Sanz L, Diaz-Meco MT, Nakano H, Moscat J. EMBO J. 2000 Apr 3;19(7):1576-86. doi: 10.1093/emboj/19.7.1576. PMID: 10747026 Free PMC article.
1999
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. Barradas M, Monjas A, Diaz-Meco MT, Serrano M, Moscat J. EMBO J. 1999 Nov 15;18(22):6362-9. doi: 10.1093/emboj/18.22.6362. PMID: 10562548 Free PMC article.
Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes. Standaert ML, Bandyopadhyay G, Perez L, Price D, Galloway L, Poklepovic A, Sajan MP, Cenni V, Sirri A, Moscat J, Toker A, Farese RV. J Biol Chem. 1999 Sep 3;274(36):25308-16. doi: 10.1074/jbc.274.36.25308. PMID: 10464256
Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. Diaz-Meco MT, Lallena MJ, Monjas A, Frutos S, Moscat J. J Biol Chem. 1999 Jul 9;274(28):19606-12. doi: 10.1074/jbc.274.28.19606. PMID: 10391896
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J. EMBO J. 1999 Jun 1;18(11):3044-53. doi: 10.1093/emboj/18.11.3044. PMID: 10356400 Free PMC article.
Cleavage of zetaPKC but not lambda/iotaPKC by caspase-3 during UV-induced apoptosis. Frutos S, Moscat J, Diaz-Meco MT. J Biol Chem. 1999 Apr 16;274(16):10765-70. doi: 10.1074/jbc.274.16.10765. PMID: 10196149
Activation of IkappaB kinase beta by protein kinase C isoforms. Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J. Mol Cell Biol. 1999 Mar;19(3):2180-8. doi: 10.1128/mcb.19.3.2180. PMID: 10022904 Free PMC article.
Effects of transiently expressed atypical (zeta, lambda), conventional (alpha, beta) and novel (delta, epsilon) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-zeta and C-lambda. Bandyopadhyay G, Standaert ML, Kikkawa U, Ono Y, Moscat J, Farese RV. Biochem J. 1999 Feb 1;337 ( Pt 3)(Pt 3):461-70. PMID: 9895289 Free PMC article.
1998
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT. Mol Cell Biol. 1998 May;18(5):3069-80. doi: 10.1128/mcb.18.5.3069. PMID: 9566925 Free PMC article.
The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. Berra E, Diaz-Meco MT, Moscat J. J Biol Chem. 1998 Apr 24;273(17):10792-7. doi: 10.1074/jbc.273.17.10792. PMID: 9553146
1997
Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. Standaert ML, Galloway L, Karnam P, Bandyopadhyay G, Moscat J, Farese RV. J Biol Chem. 1997 Nov 28;272(48):30075-82. doi: 10.1074/jbc.272.48.30075. PMID: 9374484
Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Bandyopadhyay G, Standaert ML, Galloway L, Moscat J, Farese RV. Endocrinology. 1997 Nov;138(11):4721-31. doi: 10.1210/endo.138.11.5473. PMID: 9348199
Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Berra E, Municio MM, Sanz L, Frutos S, Diaz-Meco MT, Moscat J. Mol Cell Biol. 1997 Aug;17(8):4346-54. doi: 10.1128/mcb.17.8.4346. PMID: 9234692 Free PMC article.
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Cai H, Smola U, Wixler V, Eisenmann-Tappe I, Diaz-Meco MT, Moscat J, Rapp U, Cooper GM. Mol Cell Biol. 1997 Feb;17(2):732-41. doi: 10.1128/mcb.17.2.732. PMID: 9001227 Free PMC article.
Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. Bandyopadhyay G, Standaert ML, Zhao L, Yu B, Avignon A, Galloway L, Karnam P, Moscat J, Farese RV. J Biol Chem. 1997 Jan 24;272(4):2551-8. doi: 10.1074/jbc.272.4.2551. PMID: 8999972
1996
The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J. Cell. 1996 Sep 6;86(5):777-86. doi: 10.1016/s0092-8674(00)80152-x. PMID: 8797824
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. Kirstein M, Sanz L, Quiñones S, Moscat J, Diaz-Meco MT, Saus J. J Biol Chem. 1996 Jul 26;271(30):18231-6. doi: 10.1074/jbc.271.30.18231. PMID: 8663478
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J. Mol Cell Biol. 1996 Jan;16(1):105-14. doi: 10.1128/mcb.16.1.105. PMID: 8524286 Free PMC article.
Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes. Folgueira L, McElhinny JA, Bren GD, MacMorran WS, Diaz-Meco MT, Moscat J, Paya CV. J Virol. 1996 Jan;70(1):223-31. doi: 10.1128/JVI.70.1.223-231.1996. PMID: 8523529 Free PMC article.
1995
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. Berra E, Díaz-Meco MT, Lozano J, Frutos S, Municio MM, Sánchez P, Sanz L, Moscat J. EMBO J. 1995 Dec 15;14(24):6157-63. PMID: 8557035 Free PMC article.
Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival. Martínez-Gimeno C, Díaz-Meco MT, Domínguez I, Moscat J. Head Neck. 1995 Nov-Dec;17(6):516-25. doi: 10.1002/hed.2880170609. PMID: 8847210
Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C. Bjørkøy G, Overvatn A, Diaz-Meco MT, Moscat J, Johansen T. J Biol Chem. 1995 Sep 8;270(36):21299-306. doi: 10.1074/jbc.270.36.21299. PMID: 7673165
Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta. Municio MM, Lozano J, Sánchez P, Moscat J, Diaz-Meco MT. J Biol Chem. 1995 Jun 30;270(26):15884-91. doi: 10.1074/jbc.270.26.15884. PMID: 7541049
Molecular characterization of a novel transcription factor that controls stromelysin expression. Sanz L, Moscat J, Diaz-Meco MT. Mol Cell Biol. 1995 Jun;15(6):3164-70. doi: 10.1128/mcb.15.6.3164. PMID: 7760812 Free PMC article.
1994
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. Diaz-Meco MT, Lozano J, Municio MM, Berra E, Frutos S, Sanz L, Moscat J. J Biol Chem. 1994 Dec 16;269(50):31706-10. PMID: 7989344
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. Lozano J, Berra E, Municio MM, Diaz-Meco MT, Dominguez I, Sanz L, Moscat J. J Biol Chem. 1994 Jul 29;269(30):19200-2. PMID: 8034680
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J. EMBO J. 1994 Jun 15;13(12):2842-8. PMID: 8026469 Free PMC article.
Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. Sanz L, Berra E, Municio MM, Dominguez I, Lozano J, Johansen T, Moscat J, Diaz-Meco MT. J Biol Chem. 1994 Apr 1;269(13):10044-9. PMID: 8144503
NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype. Johansen T, Bjørkøy G, Overvatn A, Diaz-Meco MT, Traavik T, Moscat J. Mol Cell Biol. 1994 Jan;14(1):646-54. doi: 10.1128/mcb.14.1.646. PMID: 8264633 Free PMC article.
1993
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Cai H, Erhardt P, Troppmair J, Diaz-Meco MT, Sithanandam G, Rapp UR, Moscat J, Cooper GM. Mol Cell Biol. 1993 Dec;13(12):7645-51. doi: 10.1128/mcb.13.12.7645. PMID: 8246981 Free PMC article.
Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. Arenzana-Seisdedos F, Fernandez B, Dominguez I, Jacqué JM, Thomas D, Diaz-Meco MT, Moscat J, Virelizier JL. J Virol. 1993 Nov;67(11):6596-604. doi: 10.1128/JVI.67.11.6596-6604.1993. PMID: 8411362 Free PMC article.
Protein kinase C zeta isoform is critical for mitogenic signal transduction. Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, Chapkin RS, Moscat J. Cell. 1993 Aug 13;74(3):555-63. doi: 10.1016/0092-8674(93)80056-k. PMID: 7688666
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation. Diaz-Meco MT, Berra E, Municio MM, Sanz L, Lozano J, Dominguez I, Diaz-Golpe V, Lain de Lera MT, Alcamí J, Payá CV, Arenzana-Seisedos F, Virelizier JL, Moscat J, et al. Mol Cell Biol. 1993 Aug;13(8):4770-5. doi: 10.1128/mcb.13.8.4770. PMID: 8336714 Free PMC article.
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Dominguez I, Sanz L, Arenzana-Seisdedos F, Diaz-Meco MT, Virelizier JL, Moscat J. Mol Cell Biol. 1993 Feb;13(2):1290-5. doi: 10.1128/mcb.13.2.1290. PMID: 8423794 Free PMC article.
1992
Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction. Cai H, Erhardt P, Szeberényi J, Diaz-Meco MT, Johansen T, Moscat J, Cooper GM. Mol Cell Biol. 1992 Dec;12(12):5329-35. doi: 10.1128/mcb.12.12.5329. PMID: 1448068 Free PMC article.
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Dominguez I, Diaz-Meco MT, Municio MM, Berra E, García de Herreros A, Cornet ME, Sanz L, Moscat J. Mol Cell Biol. 1992 Sep;12(9):3776-83. doi: 10.1128/mcb.12.9.3776. PMID: 1508183 Free PMC article.
Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals. Diaz-Meco MT, Dominguez I, Sanz L, Municio MM, Berra E, Cornet ME, Garcia de Herreros A, Johansen T, Moscat J. Mol Cell Biol. 1992 Jan;12(1):302-8. doi: 10.1128/mcb.12.1.302. PMID: 1309592 Free PMC article.
1991
Protein kinase C-independent expression of stromelysin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C. Diaz-Meco MT, Quiñones S, Municio MM, Sanz L, Bernal D, Cabrero E, Saus J, Moscat J. J Biol Chem. 1991 Nov 25;266(33):22597-602. PMID: 1718997
Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. Dominguez I, Marshall MS, Gibbs JB, García de Herreros A, Cornet ME, Graziani G, Diaz-Meco MT, Johansen T, McCormick F, Moscat J. EMBO J. 1991 Nov;10(11):3215-20. PMID: 1655413 Free PMC article.
Effect of ethanol on arachidonic acid metabolism in macrophages. Schüller A, Aracil M, Diez E, Moscat J, Serrano Ríos M, Municio AM. Riv Eur Sci Med Farmacol. 1991 May-Aug;13(3-4):105-13. PMID: 1821045
Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. García de Herreros A, Dominguez I, Diaz-Meco MT, Graziani G, Cornett ME, Guddal PH, Johansen T, Moscat J. J Biol Chem. 1991 Apr 15;266(11):6825-9. PMID: 2016297
Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C. Diaz-Laviada I, Larrodera P, Nieto JL, Cornet ME, Diaz-Meco MT, Sanchez MJ, Guddal PH, Johansen T, Haro A, Moscat J. J Biol Chem. 1991 Jan 15;266(2):1170-6. PMID: 1845988
1990
Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes. Diaz-Laviada I, Larrodera P, Diaz-Meco MT, Cornet ME, Guddal PH, Johansen T, Moscat J. EMBO J. 1990 Dec;9(12):3907-12. PMID: 2123453 Free PMC article.
Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Larrodera P, Cornet ME, Diaz-Meco MT, Lopez-Barahona M, Diaz-Laviada I, Guddal PH, Johansen T, Moscat J. Cell. 1990 Jun 15;61(6):1113-20. doi: 10.1016/0092-8674(90)90074-o. PMID: 2112426
Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade. Lopez-Barahona M, Kaplan PL, Cornet ME, Diaz-Meco MT, Larrodera P, Diaz-Laviada I, Municio AM, Moscat J. J Biol Chem. 1990 Jun 5;265(16):9022-6. PMID: 2188971
1989
Activation of phosphatidylcholine-specific phospholipase C in cell growth and oncogene transformation. Moscat J, Cornet ME, Diaz-Meco MT, Larrodera P, Lopez-Alanon D, Lopez-Barahona M. Biochem Soc Trans. 1989 Dec;17(6):988-91. doi: 10.1042/bst0170988. PMID: 2560749 Review. No abstract available.
Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonistsDiaz-Meco MT, Larrodera P, Lopez-Barahona M, Cornet ME, Barreno PG, Moscat J. Biochem J. 1989 Oct 1;263(1):115-20. doi: 10.1042/bj2630115. PMID: 2557819 Free PMC article.
The calcium signal for Balb/MK keratinocyte terminal differentiation induces sustained alterations in phosphoinositide metabolism without detectable protein kinase C activation. Moscat J, Fleming TP, Molloy CJ, Lopez-Barahona M, Aaronson SA. J Biol Chem. 1989 Jul 5;264(19):11228-35. PMID: 2472392
1988
Ca2+-induced changes in the secondary structure of a 60 kDa phosphoinositide-specific phospholipase C from bovine brain cytosol. Herrero C, Cornet ME, Lopez C, Barreno PG, Municio AM, Moscat J. Biochem J. 1988 Nov 1;255(3):807-12. doi: 10.1042/bj2550807. PMID: 2850798 Free PMC article.
Epidermal growth factor activates phosphoinositide turnover and protein kinase C in BALB/MK keratinocytes. Moscat J, Molloy CJ, Fleming TP, Aaronson SA. Mol Endocrinol. 1988 Sep;2(9):799-805. doi: 10.1210/mend-2-9-799. PMID: 2459606
Endothelial cell growth factor and ionophore A23187 stimulation of production of inositol phosphates in porcine aorta endothelial cells. Moscat J, Moreno F, Herrero C, López C, García-Barreno P. Proc Natl Acad Sci U S A. 1988 Feb;85(3):659-63. doi: 10.1073/pnas.85.3.659.PMID: 3124109 Free PMC article.
1987
Effect of ethanol on the arachidonic acid metabolism in mouse peritoneal macrophages. Moscat J, Aracil M, Diez E, Garcia-Barreno P, Municio AM. Prostaglandins. 1987 Dec;34(6):853-66. doi: 10.1016/0090-6980(87)90066-9.PMID: 2835790
Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21. Lacal JC, de la Peña P, Moscat J, Garcia-Barreno P, Anderson PS, Aaronson SA. Science. 1987 Oct 23;238(4826):533-6. doi: 10.1126/science.2821623. PMID: 2821623
Mitogenic activity and inositide metabolism in thrombin-stimulated pig aorta endothelial cells. Moscat J, Moreno F, García-Barreno P. Biochem Biophys Res Commun. 1987 Jun 30;145(3):1302-9. doi: 10.1016/0006-291x(87)91579-8. PMID: 3111467
Zymosan-induced release of inositol phosphates at resting cytosolic Ca2+ concentrations in macrophages. Moscat J, Herrero C, Garcia-Barreno P, Municio AM. Biochem J. 1987 Mar 1;242(2):441-5. doi: 10.1042/bj2420441. PMID: 3109391 Free PMC article.
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Lacal JC, Moscat J, Aaronson SA. Nature. 1987 Nov 19-25;330(6145):269-72. doi: 10.1038/330269a0. PMID: 3313065
A new family with hereditary choreo-acanthocytosis. Villegas A, Moscat J, Vazquez A, Calero F, Alvarez-Sala JL, Artola S, Espinós D. Acta Haematol. 1987;77(4):215-9. doi: 10.1159/000205998. PMID: 3115032
Effects of Escherichia coli lipopolysaccharide on the phosphoinositide metabolism and serotonin secretion in thrombin-activated platelets. Moscat J, Iglesias S, Moreno F, Herrero C, Garcia-Barreno P. Circ Shock. 1987;23(2):85-92. PMID: 2824090
1986
Phospholipase C-diglyceride lipase is a major pathway for arachidonic acid release in macrophages. Moscat J, Herrero C, Garcia-Barreno P, Municio AM. Biochem Biophys Res Commun. 1986 Nov 26;141(1):367-73. doi: 10.1016/s0006-291x(86)80378-3. PMID: 3099782
Membrane fluidity and thromboxane synthesis in platelets from patients with severe atherosclerosis. Moscat J, Perez P, Gavilanes FG, Acin F, Schuller A, Municio AM. Thromb Res. 1986 Oct 15;44(2):197-205. doi: 10.1016/0049-3848(86)90135-0. PMID: 3097871
Arachidonic acid releasing systems in pig aorta endothelial cells. Moscat J, Moreno F, Herrero C, Iglesias S, Garcia-Barreno P. Biochem Biophys Res Commun. 1986 Sep 30;139(3):1098-103. doi: 10.1016/s0006-291x(86)80290-x. PMID: 3094524
The fluidity of liver plasma membranes from patients with different types of liver injury. Schuller A, Solis-Herruzo JA, Moscat J, Fernandez-Checa JC, Municio AM. Hepatology. 1986 Jul-Aug;6(4):714-7. doi: 10.1002/hep.1840060429. PMID: 3015760
Intracellular Ca2+ requirements for zymosan-stimulated phosphoinositide hydrolysis in mouse peritoneal macrophages. Moscat J, Aracil M, Diez E, Balsinde J, Garcia Barreno P, Municio AM. Biochem Biophys Res Commun. 1986 Jan 14;134(1):367-71. doi: 10.1016/0006-291x(86)90572-3. PMID: 3004439
1985
Functional properties of isolated hepatocytes from ethanol-treated rat liver. Schüller A, Moscat J, Diez E, Fernandez-Checa JC, Gavilanes FG, Municio AM. Hepatology. 1985 Jul-Aug;5(4):677-82. doi: 10.1002/hep.1840050426. PMID: 3894201
1984
The fluidity of plasma membranes from ethanol-treated rat liver. Schüller A, Moscat J, Diez E, Fernandez-Checa C, Gavilanes FG, Municio AM. Mol Cell Biochem. 1984 Sep;64(1):89-95. doi: 10.1007/BF00420932. PMID: 6493225