https://www.moscatdiazmecolab.org/pb1-network-in-intestine-and-colon daily 0.75 2024-06-19 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611869861548-KTQMN7JMB4O3CI2PSQUL/Intestine.jpg Intestinal Cancer https://www.moscatdiazmecolab.org/pb1-network-in-liver daily 0.75 2024-12-16 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611863374148-LN9BQPLPZ63YJ19DRJWI/Liver.jpg Liver Cancer https://www.moscatdiazmecolab.org/home daily 1.0 2025-03-17 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/9b5faf27-92b8-4039-85e9-909f48b27eb1/nyc-lab-home-dec23-FINAL2.jpg https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/9fb9a1f2-6f08-4d49-8eed-9757baeafdd8/Screenshot+2024-12-16+at+3.24.25%E2%80%AFPM.png https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/32bda61e-4fcb-42b3-b323-b268258f85da/Screenshot+2024-12-15+at+8.25.34%E2%80%AFAM.png https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/ca4ec921-723b-4d21-a8fd-4dda2a611791/Screenshot+2024-12-15+at+8.27.09%E2%80%AFAM.png https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/926bdf20-4ce7-40a8-93d6-7468f5d3ac56/Screenshot+2024-12-16+at+3.22.37%E2%80%AFPM.png https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1c6823d3-4417-42f1-865b-db24b9370327/Screenshot+2024-12-15+at+8.26.27%E2%80%AFAM.png https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/156af27f-b6ae-46b6-8ff6-7d574918eca6/Screenshot+2024-12-15+at+8.25.19%E2%80%AFAM.png https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/200a3732-27a8-45e4-b7b8-ace4a4321591/Screenshot+2024-12-15+at+8.25.59%E2%80%AFAM.png https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611873495655-UQF96ASTQKRKR6OBE2B5/symposium2020_1.png MOSCAT and DIAZ-MECO LABs - Research Areas The goal of our laboratories is to unravel the molecular and cellular mechanisms of cancer, creating synergies between the two labs to find common and specific vulnerabilities in each type of tumor. Only by understanding the enemy can we beat it! https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611705720668-8W9NHVJT98LFOHVUEFYM/image001.jpg MOSCAT and DIAZ-MECO LABs - JOIN US We are Weill Cornell Medicine investigators located in the Belfer Research Building in Manhattan, New York. We invite scientists of all stages (post-docs, graduate students, clinical fellows, undergraduate students, research associates) to join our team and contribute with exciting discoveries to help cure cancer. Join the fight! https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/f6055e34-9fe0-495e-8b77-884bbf4b54f8/Screenshot+2024-12-16+at+7.21.49%E2%80%AFPM.png MOSCAT and DIAZ-MECO LABs - Our team We are a multidisciplinary group of scientists passionate about science and medicine and determined to understand how cells are transformed into tumors. We want to contribute to the fight to eradicate cancer by making impactful discoveries and training the next generation of scientists. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/af4d36da-b71e-4fc0-aa83-a1cfb81d526a/Publications_121624.png MOSCAT and DIAZ-MECO LABs - Publications We aim to disseminate our findings in high-impact publications https://www.moscatdiazmecolab.org/team daily 0.75 2025-03-14 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611863841328-0MCV851RJM701I43VXH4/MARIA.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611837804269-0KTCYAM8RTS8HG5U5BRA/Moscat-1-1.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611932489575-C7K6SNBKMTNC9IN22EIH/ANGELES.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611931871987-W53O9R9WIC9PZR860WOY/IMG_9323+2.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611849724426-QE1HV3QWB6NP4LG059YZ/HIROTO1.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611795756441-IJ1JAA5RQ1947DI4K3I7/PHOTO-2020-09-03-13-03-37.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611932216967-Y0VXLNUJGHRNSAR1KND9/IMG_9309-1.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611853939849-B0JANFCC5MOWR5NEGAI7/XIAO1.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611849865039-HJDVN9HRHW8AHMA1TFN3/MARC1.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611931796388-E2FXQKM6TY98G6MSDBWI/IMG_9344+3.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611849906904-TCAIGNBZQSVV0SSXXFAR/SHANKHA1.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1627158799642-EHC7QOTPN2WXV5I5DLLW/Sadaaki_new+copy.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/fadb0583-f970-4d7f-b2a8-289c25ff043f/Dajun.jpg Team - Make it stand out Dajun Qu, PhD https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/4bc1e274-b654-4a60-bdcc-5a4c78b16822/YusukeSakamoto.jpg Team - Make it stand out Yusuke Sakamoto, MD, PhD https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1627158951768-KFXQKX9EHRPRZF9MTLWQ/Imran1+copy.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1627159109564-ZYAW5D4Z5FX18TLYPQFU/Marta+copy.jpg Team https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/ddc38dfe-e81d-434d-aac0-61176f359895/Darla.jpg https://www.moscatdiazmecolab.org/publications daily 0.75 2024-12-16 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611689041523-Z31TVDN4W7CU81OLR471/Huang2018.jpg Featured Publications - Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor. Huang J, Duran A, Reina-Campos M, Valencia T, Castilla EA, Müller TD, Tschöp MH, Moscat J, Diaz-Meco MT. Cancer Cell. 2018 Apr 9;33(4):770-784.e6. doi: 10.1016/j.ccell.2018.03.001. PMID:29634950 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611692563775-KQ9WVKKWQOMOPGM977T6/Kudo2020.jpg Featured Publications - PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. Cancer Cell. 2020 Aug 10;38(2):247-262.e11. doi: 10.1016/j.ccell.2020.05.018. Epub 2020 Jun 25. PMID: 32589943 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/fc0a579f-d2bb-4cd7-9d60-30818f0037ee/AMO2022.jpeg Featured Publications - Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer Martinez-Ordoñez A, Duran A, Ruiz-Martinez M, Cid-Diaz T, Zhang X, Han Q, Kinoshita H, Muta Y, Linares JF, Kasashima H, Nakanishi Y, Omar M, Nishimura S, Avila L, Yashiro M, Maeda K, Pannellini T, Pigazzi A, Inghirami G, Marchionni L, Sigal D, Diaz-Meco MT, Moscat J. Cancer Cell. 2023 Feb 13;41(2):252-271.e9. doi: 10.1016/j.ccell.2022.11.016. Epub 2022 Dec 15.PMID: 36525970 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611695212836-8EX43SMQU9ACUZ6BWV0J/Duran2016.jpg Featured Publications - p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. Cancer Cell. 2016 Oct 10;30(4):595-609. doi: 10.1016/j.ccell.2016.09.004. PMID:27728806 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611697758636-WZD0WHE37K7KQCXW2UV5/Linares2015.jpg Featured Publications - Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade. Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J, Diaz-Meco MT. Cell Rep. 2015 Aug 25;12(8):1339-52. doi: 10.1016/j.celrep.2015.07.045. Epub 2015 Aug 13. PMID:26279575 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611698322765-HGPOCLOO1Y31CSRLTM2K/Valencia2014.jpg Featured Publications - Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Valencia T, Kim JY, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco MT, Moscat J. Cancer Cell. 2014 Jul 14;26(1):121-135. doi: 10.1016/j.ccr.2014.05.004. Epub 2014 Jul 4. PMID:25002027 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611697406348-ZMTQW8QPLSZ0MSKP6XEE/Nakanishi2016.jpg Featured Publications - Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι. Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J. Cell Rep. 2016 Sep 20;16(12):3297-3310. doi: 10.1016/j.celrep.2016.08.054. PMID:27653691 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1632408776164-9NWTLYXI3G6KHG881WAZ/LINARES2021_graphical.jpeg Featured Publications - PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis Linares JF, Zhang X, Martinez-Ordoñez A, Duran A, Kinoshita H, Kasashima H, Nakanishi N, Nakanishi Y, Carelli R, Cappelli L, Arias E, Yashiro M, Ohira M, Patel S, Inghirami G, Loda M, Cuervo AM, Diaz-Meco MT, Moscat J. Mol Cell. 2021 Nov 4;81(21):4509-4526.e10. doi: 10.1016/j.molcel.2021.08.039. Epub 2021 Sep 23. PMID: 34560002 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611692448130-JHJUS8AZSW4K24NV9B8F/Reina2019.jpg Featured Publications - Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K, Beltran H, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT. Cancer Cell. 2019 Mar 18;35(3):385-400.e9. doi: 10.1016/j.ccell.2019.01.018. Epub 2019 Feb 28. PMID:30827887 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/5a2986dc-8817-4e99-b6c1-e8f0be74eccc/Screenshot+2024-12-16+at+3.22.37%E2%80%AFPM.png Featured Publications - Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer Chatterjee SS, Linares JF, Cid-Diaz T, Duran A, Khan MIK, Osrodek M, Brady NJ, Reina-Campos M, Marzio A, Venkadakrishnan VB, Bakht MK, Khani F, Mosquera JM, Robinson BD, Moyer J, Elemento O, Hsieh AC, Goodrich DW, Rickman DS, Beltran H, Moscat J, Diaz-Meco MT. Nat Commun. 2024 Nov 20;15(1):9755. doi: 10.1038/s41467-024-53874-2. PMID: 39567499; PMCID: PMC11579030. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/76c2d7c6-99a0-493a-9f10-237d08df6811/Screenshot+2024-10-21+at+9.30.55%E2%80%AFPM.png Featured Publications - Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma Nishimura S, Linares JF, L’Hermitte A, Duran A, Cid-Diaz T, Martinez-Ordoñez A, Ruiz-Martinez, M, Kudo Y, Marzio A, Heikenwalder M, Roberts LR, Diaz-Meco MT, Moscat J. Mol Cell. 2024 Oct 14:S1097-2765(24)00782-2. doi: 10.1016/j.molcel.2024.09.026. Epub ahead of print. PMID: 39423823. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611689113375-28M2P9X15GXJCPQVG01V/Sheelton2018.jpg Featured Publications - The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer. Shelton PM, Duran A, Nakanishi Y, Reina-Campos M, Kasashima H, Llado V, Ma L, Campos A, García-Olmo D, García-Arranz M, García-Olmo DC, Olmedillas-López S, Caceres JF, Diaz-Meco MT, Moscat J. Cell Rep. 2018 Apr 24;23(4):1178-1191. doi: 10.1016/j.celrep.2018.03.118. PMID:29694894 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1621470028749-7TS7DY7O9OSGIK8Z99JX/41467_2021_23085_Fig9_HTML.jpg Featured Publications - NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ Huang J, Linares JF, Duran A, Xia W, Saltiel AR, Müller TD, Diaz-Meco MT, Moscat J. Nat Commun. 2021 May 17;12(1):2876. doi: 10.1038/s41467-021-23085-0. PMID: 34001883 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/6cb6d547-9dde-478b-a342-a51e10c0f761/Screenshot+2023-12-22+at+9.01.36+AM.png Featured Publications - Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis Muta Y, Linares JF, Martinez-Ordoñez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, Garcia-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J. Nat Commun 14, 8075 (2023). https://doi.org/10.1038/s41467-023-43690-5 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611697791277-VLPHETGIV15X7GVRCWZ5/Llado2015.jpg Featured Publications - Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Llado V, Nakanishi Y, Duran A, Reina-Campos M, Shelton PM, Linares JF, Yajima T, Campos A, Aza-Blanc P, Leitges M, Diaz-Meco MT, Moscat J. Cell Rep. 2015 Feb 10;10(5):740-754. doi: 10.1016/j.celrep.2015.01.007. Epub 2015 Feb 5. PMID:25660024 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611698342208-JA07Q0ZQUGO08ZXBSNV1/Ma2012.jpg Featured Publications - Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J. Cell. 2013 Jan 31;152(3):599-611. doi: 10.1016/j.cell.2012.12.028. PMID:23374352 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/082906a0-c328-4ddf-bc0c-088a2e16215f/fx1_lrg.jpg Featured Publications - Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation Kinoshita H, Martinez-Ordoñez A, Cid-Diaz T, Han Q, Duran A, Muta Y, Zhang X, Linares JF, Nakanishi Y, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, Garcia-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Diaz-Meco MT, Moscat J. Developmental Cell 59, 1-16, (2024). https://doi.org/10.1016/j.devcel.2024.05.001. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611698299216-W70Q6B7CS6J7D42MXIHC/Hernandez2014.jpg Featured Publications - A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J. Cell Metab. 2014 Sep 2;20(3):499-511. doi: 10.1016/j.cmet.2014.06.008. Epub 2014 Jul 17. PMID:25043814 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611692496888-OWGAIAMD5WX02YVU3J3A/Nakanishi2018.jpg Featured Publications - Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J. Immunity. 2018 Dec 18;49(6):1132-1147.e7. doi: 10.1016/j.immuni.2018.09.013. Epub 2018 Dec 11. PMID:30552022 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611690778084-OFZLVE0T5I64RFYDQAUG/Linares2017.jpg Featured Publications - ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PMID:28988820 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/dacec581-c35f-450e-9315-7ead3b82dd70/Lactate_Figure_Graphical_v3.png Featured Publications - The lactate-NAD + axis activates cancer-associated fibroblasts by downregulating p62 Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo H, Elemento O, Martin L, Cordes T, Thompson T, Metallo C, Moscat J, Diaz-Meco MT. Cell Rep. 2022 May 10, 39, 110792. doi: 10.1016/j.celrep.2022.110792. PMID: 35545049 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611690970349-PXSNEE2CXR29NG5JEIEN/Kasashima2020.jpg Featured Publications - Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population Kasashima H, Duran A, Martinez-Ordoñez A, Nakanishi Y, Kinoshita H, Linares JF, Reina-Campos M, Kudo Y, L'Hermitte A, Yashiro M, Ohira M, Bao F, Tauriello DVF, Batlle E, Diaz-Meco MT, Moscat J. Dev Cell. 2021 Jan 11;56(1):95-110.e10. doi: 10.1016/j.devcel.2020.10.014. Epub 2020 Nov 17. PMID: 33207226 https://www.moscatdiazmecolab.org/pb1-network-in-prostate daily 0.75 2024-12-16 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611868835781-8CZI6LZA1KTOLBPY1HME/Prostate4.jpg Prostate Cancer Acquired resistance to targeted therapies in cancer is a rising unmet clinical need. In prostate cancer (PCa), the success of next-generation androgen receptor (AR) pathway inhibitors has been hampered by the development of drug resistance. This acquired resistance involves, in many cases, the reactivation of the AR axis through several different mechanisms. However, an alternative mechanism of resistance is driven by the reprogramming of prostate cancer cells to undergo lineage plasticity to adopt an AR-independent state and to acquire a neuroendocrine phenotype, that allow them to grow and survive and escape AR-therapy. More potent and sustained AR targeting has driven an increased incidence of neuroendocrine prostate cancer (NEPC), which is an extremely aggressive, highly proliferative and metastatic PCa variant. Therefore, understanding the molecular mechanisms that govern NEPC differentiation is a pressing unmet clinical need. We are interested in unveiling the signaling and metabolic pathways that account for these changes in cell identity during therapy resistance with the goal of identifying new targets that either restore sensitivity to current therapeutics or that exploit new previously unanticipated tumor cell vulnerabilities. Our recent studies have discovered that the downregulation of PKCl/i is a hallmark of human NEPC patients. We demonstrated that the loss of PKCl/i results in the upregulation of the serine and one-carbon pathway that leads to increased production of S-adenosine methionine, universal and obligated methyl donor for DNA and histone methylation. Our present work aims to unravel the epigenetic mechanisms linking metabolic reprogramming by PKCl/i to cell lineage alterations in PCa and possibly therapy resistance in other types of cancers. We are also investigating how the remodeling of the tumor microenvironment, particularly the stromal fibroblasts, facilitates therapy resistance, and how the metabolic interplay between cancer-associated fibroblasts and the epithelial compartment of the tumor informs new therapies. https://www.moscatdiazmecolab.org/lab-alumni daily 0.75 2021-01-29 https://www.moscatdiazmecolab.org/full-list-of-publications daily 0.75 2024-12-12 https://www.moscatdiazmecolab.org/the-molecules daily 0.75 2021-01-29 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611855735995-H0JIPBN884FH52SRWRU4/image001.png The Molecules PB1 structure https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611855769149-OMGHYEBFSA3AVC76B7KA/Screen+Shot+2021-01-28+at+10.20.55+AM.png The Molecules p62, autophagy and signaling integrator https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611855753142-24ZY0S62OVQTKTSW4NH7/Screen+Shot+2021-01-28+at+10.19.45+AM.png The Molecules PB1 network https://www.moscatdiazmecolab.org/protocols daily 0.75 2024-12-17 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/7274bd97-9f1f-4954-9846-7df0233b0153/Screenshot+2024-09-26+at+6.43.49%E2%80%AFPM.png Protocols Protocol to characterize mouse intestinal epithelial cell lineage using Opal multiplex immunofluorescence Anxo Martinez-Ordoñez, Hiroto Kinoshita, Tania Cid-Diaz, Angeles Duran, Marta Osrodek, Maria T. Diaz-Meco, Jorge Moscat, Protocol to characterize mouse intestinal epithelial cell lineage using Opal multiplex immunofluorescence, STAR Protoc. 2024 Sep 20;5(3):103303. doi: 10.1016/j.xpro.2024.103303. Epub 2024 Sep 12. PMID: 39264806 Free article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/85f99a62-07aa-46cc-bff6-318161b5104c/1-s2.0-S2666166723002010-fx1_lrg.jpg Protocols Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures Martinez-Ordoñez A, Cid-Diaz T, Duran A, Han Q, Moscat J, Diaz-Meco, MT. STAR Protoc. 2023 Apr 20;4(2):102243. doi: 10.1016/j.xpro.2023.102243. Online ahead of print. PMID: 37083323 Free article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/832625eb-54a0-4f7c-9fa6-9ef9cac39578/Screen+Shot+2022-09-06+at+11.50.30+AM.png Protocols - Air-liquid organotypic assays to investigate cellular crosstalk in the tumor microenvironment of cancer cells Cid-Diaz T, Lodeiro AC, Duran A, Moscat J, Diaz-Meco, MT. STAR Protoc. 2022 Aug 18;3(3):101635. doi: 10.1016/j.xpro.2022.101635. eCollection 2022 Sep 16. PMID: 36035805 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611255786241-1SAGYOAOSZC253QGM8AI/Screen+Shot+2021-01-21+at+12.50.55+PM.png Protocols - Mouse model of Colorectal Cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum Kasashima H, Duran A, Cid-Diaz T, Muta Y, Kinoshita H, Batlle E, Diaz-Meco MT, Moscat J. STAR Protoc. 2021 Jan 22;2(1):100297. doi: 10.1016/j.xpro.2021.100297. eCollection 2021 Mar 19. PMID: 33554135 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611256183845-3ZKFEYPQ7229ZS2O1G6E/Screen+Shot+2021-01-21+at+2.09.11+PM.png Protocols - An Orthotopic Implantation Mouse Model of Hepatocellular Carcinoma with Underlying Liver Steatosis. Kasashima H, Duran A, Cid-Diaz T, Kudo Y, Diaz-Meco MT, Moscat J. STAR Protoc. 2020 Nov 20;1(3):100185. doi: 10.1016/j.xpro.2020.100185. eCollection 2020 Dec 18. PMID: 33377079 Free PMC article. https://www.moscatdiazmecolab.org/join-us daily 0.75 2022-10-27 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/d5e95083-78ff-4e64-aa72-fb8537615076/image002-enhanced1.jpg Join us https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/0373765e-4d3c-478d-abe6-7e3d54e0bf10/Quote1.jpg Join us https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611846468427-J1XOF0EZUYAJ02OB67BQ/Weiss_BUIlding_web.jpg Join us https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611846099397-0Z01Z3QZGW6R77L92MWV/MAP_web.jpg Join us https://www.moscatdiazmecolab.org/cancer-biology-symposia daily 0.75 2022-11-12 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1703275894114-1LNSMTY3QQ8PSJF4GT15/WCM-Symposium2023-2.jpg Cancer Biology Symposia https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/88be30fb-0a1d-47f9-87bd-634412cda3e1/WCM-Symposium2022-Revised-2_AD.jpg Cancer Biology Symposia https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/4e37cf16-4594-45b2-86e6-0518f71427a7/symposium2018-4-ad.jpg Cancer Biology Symposia https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611850215494-ZIVFHBV7V5C47UTVJ7WR/Cancer+Metabolism+Sym+2016.jpg Cancer Biology Symposia https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611850858114-Q1ZUU1E0VNAPWQNLX47V/Cancer+Metabolism+Sym+2014.jpg Cancer Biology Symposia https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611850958235-YZK4QGSA4UU29G9V0J3H/Cancer+Metabolism+Sym+2012.jpg Cancer Biology Symposia https://www.moscatdiazmecolab.org/pb1-network-in-stroma daily 0.75 2021-01-29 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611872990885-QI4J5RF0T79U5NZ2S2BI/Stroma-web.jpg Stromal activation and Tumor Progression https://www.moscatdiazmecolab.org/selected-recent-reviews daily 0.75 2022-06-29 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/9a5ae2c8-4c40-4a25-b552-abb30d1123be/Rev_Moscat2022.jpg Selected recent reviews https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611951103030-QUVYMEEGJY2KLT31KK8K/REv_Reina2019.jpg Selected recent reviews https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611950835594-MTMHETZVTL9GAN867CSV/Rev_Reina2020.jpg Selected recent reviews https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611951604806-YJZVKD4TC5LLPPS1CZ0H/REv_Nakanishi2020.jpg Selected recent reviews https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611951779223-SXHFD773444QP9LLHBIN/REv_Moscat2016.jpg Selected recent reviews https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611951923420-5UO43ACRL0VBXUVZWNY0/Rev_Moscat2011.jpg Selected recent reviews https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611952058682-LIIMMJAYHKUB7K7YGIMP/Rev_Moscat2009.jpg Selected recent reviews https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611959241892-W337PB42JQL3XRDKIXLU/revPB1+copy.jpg Selected recent reviews - Cell signaling and function organized by PB1 domain interactions. Moscat J, Diaz-Meco MT, Albert A, Campuzano S. Mol Cell. 2006 Sep 1;23(5):631-40. doi: 10.1016/j.molcel.2006.08.002.PMID: 16949360 Review. The PB1-domain-containing proteins p62, aPKC, MEKK2/MEKK3, MEK5, and Par-6 play roles in critical cell processes like osteoclastogenesis, angiogenesis, and early cardiovascular development or cell polarity. PB1 domains are scaffold modules that adopt the topology of ubiquitin-like beta-grasp folds that interact with each other in a front-to-back mode to arrange heterodimers or homo-oligomers. The different PB1 domain adaptors provide specificity for PB1 kinases to ensure the effective transmission of cellular signals. Also, recent data suggest that PB1 domains may serve to orchestrate signaling cascades not involving other PB1 domains, such as the MEK5-ERK5 and p62-ERK1 interactions. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611953166017-86DR09WR0PD43OQQB2SS/Rev_ReinaCampos2018.jpg Selected recent reviews https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611953334422-ACJUMLW20GMZQZ1M8VM5/Rev_ReinaCampos20182.jpg Selected recent reviews https://www.moscatdiazmecolab.org/maria-t-diaz-meco daily 0.75 2021-01-29 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611948113677-J8OJSUHE6QKQM9W90DAR/IMG_9366-rev.jpg Maria T. Diaz-Meco - Maria T. Diaz-Meco Maria T. Diaz-Meco studies the molecular and cellular mechanisms that control therapy resistance, with a particular interest in the regulation of lineage plasticity in prostate cancer. Her current approach is to identify metabolic and epigenetic vulnerabilities that will serve as therapeutic targets for new anti-cancer medicines that selectively impact tumor cell growth and survival. Diaz-Meco recently identified the metabolic pathways underlying the acquisition of therapy-resistance in patients of the most aggressive form of metastatic prostate cancer. These studies unraveled potential targets in the control of the metabolic and epigenetic programs whose therapeutic manipulation could restore sensitivity to androgen-deprivation therapy to patients that have become refractory to this type of treatment. Maria is also interested in the metabolic impact of stromal reprogramming and the crosstalk of the tumor cell and its microenvironment during tumor initiation and progression in prostate cancer. The overall goal of her projects is to study metabolism and inflammation in prostate cancer, understand this disease's biology, and identify potentially novel therapeutic targets. Maria T. Diaz-Meco earned a bachelor’s degree in Chemistry and her Ph.D. in Biochemistry & Molecular Biology at the University Complutense in Madrid, Spain, with graduate training studies at the National Cancer Institute. She was an Associate Professor in the National Research Council of Spain when she was recruited in 2006 to the Genome Research Institute at the University of Cincinnati. In 2010, she was appointed Professor of Cancer and Cell Biology at the University of Cincinnati Medical College, and in 2011 she joined the Sanford Burnham Prebys Medical Discovery Institute as Professor in the Cancer Metabolism and Signaling Networks Program. In 2020, she was recruited to Weill Cornell Medicine as Professor in the Department of Pathology and Laboratory Medicine. Since January 2021, she is a Homer T. Hirst III Professor of Oncology in Pathology at WCM. https://www.moscatdiazmecolab.org/jorge-and-maria daily 0.75 2021-01-29 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611867054800-C5FMJ4GNAABXLIBQNNZI/image001%2B2.jpg Jorge Moscat - Jorge Moscat, PhD Jorge Moscat is a Cancer Biologist with expertise in the cellular and molecular mechanisms that control the initiation and progression of tumors. He focuses on liver and colorectal cancer and has made impactful contributions to understanding the metabolic and immunological landscape of these tumors and their response to immunotherapy. His research aims to identify non-oncogenic vulnerabilities in cancer, with a particular interest in the interface between inflammation and metabolism. Jorge’s work led to the identification and characterization of several novel signaling molecules such as the autophagy and PB1-containing signaling adaptors p62/SQSTM1 and NBR1, and the PB1 kinases PKCz and PKCl/i. He has served in numerous scientific and leadership positions, including being an elected member of the prestigious European Molecular Biology Organization. Jorge Moscat presently is a Homer T. Hirst III Professor of Oncology in Pathology and Vice-Chair for Experimental Pathology at the Weill Cornell Medical College. Before joining Cornell, Jorge has served in several leadership positions at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla (California), including Deputy Director of the Cancer Center and also as the Institute’s Director of Metabolism Initiatives. Before that, Jorge was a Professor and Chairman of the Department of Cancer and Cell Biology and Associate Director of the Cincinnati Cancer Consortium at the University of Cincinnati Medical College. He also served in several positions in the National Research Council of Spain, in which he was a Professor and Director of the Institute for Molecular Biology. https://www.moscatdiazmecolab.org/gallery daily 0.75 2024-12-16 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611079643190-882BY3HSX5634ARR3ZIQ/IMG_0959.JPG Gallery https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611079866353-UGMVP9LANWU737SX5SGL/IMG_0732.jpg Gallery https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611945970472-2LZXG3LU71EEG11S8CN4/07A8AAA2-62DD-44A3-BAF1-BA5D7DCFD2A7.JPG Gallery https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611956567943-TZTQXTQJD9LZEWWH7X48/IMG_7530+%281%29.jpeg Gallery https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/8c9b8807-c029-4b6f-899c-56e6165c4440/Screenshot+2024-12-16+at+5.07.26%E2%80%AFPM.png Gallery 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https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611946308117-6OYSQKJ278SY8Q2AGAFY/IMG_3969.jpeg Gallery https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611946308031-44ECTIGOXJ8MN990DZGP/IMG_4717.jpeg Gallery https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611946308901-4984OEACKULDTQYYQUNK/IMG_5436.jpeg Gallery https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611946309299-46289XRRSOG8H2P4JR4D/IMG_5442.jpeg Gallery https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611946310119-XTTQNM1W3MVXF8TVI6FH/IMG_5547.jpeg Gallery https://www.moscatdiazmecolab.org/metabolism-and-cancer daily 0.75 2021-05-19 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611959976706-Z8U8O5MM05H29S1L2UPE/Metabolism-web.jpg Metabolism and Cancer Tumor cells have an extremely elevated need for nutrients to sustain their high anabolic requirements necessary to maintain their enhanced proliferative rate. They are tremendously plastic and can reprogram their metabolism to more effectively use nutrients, when they are abundant, and reframe several key metabolic pathways to resist nutrient deprivation when they become aggressive and in poorly vascularized microenvironments. The study of these mechanisms opened the possibility of identifying metabolic dependencies and addictions in each type of cancer cell, which in fact become vulnerabilities that can be targeted therapeutically. Our laboratories actively explore these pathways and have very significantly contributed to the field by identifying several key mechanisms in the study of tumor metabolism. These included the serine biosynthetic and one-carbon pathways that are a central node in the control of cell energetics, oxidative detoxification, and epigenetic control through the generation of methyl donor groups for DNA and histone methylation. Although part of the lab focuses on the metabolism of tumor cells, there is another aspect of this question that is of paramount importance and that deals with the question of total body metabolism, the metabolic syndrome, and its relationship with cancer. Our labs were the first to report the role of p62/SQSTM1 in adipocyte function. We showed that the loss of p62 in adipocytes triggered increased adiposity and obesity in mice. Interestingly, this has very important effects on cancer. Thus, we demonstrated that the loss of p62 in adipocytes results in increased osteopontin secretion, which mediates tumor fatty acid oxidation and invasion, leading to aggressive metastatic prostate cancer. Importantly, while promoting tumor malignancy, the adipocyte’s p62 deficiency promotes a general shutdown of energy-utilizing pathways in adipocytes through mTORC1 inhibition, which supports nutrient availability for cancer cells. These results exemplified the symbiotic collaboration between adipocytes and tumor cells in which p62 emerges as a central regulator. https://www.moscatdiazmecolab.org/home-1 daily 0.75 2022-05-16 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1621390150444-GZL59V0RCDPTWDB6STZL/PEOPLE3_051821.jpg MOSCAT and DIAZ-MECO LABs (Copy) - Our team We are a diverse and multidisciplinary international group of individuals passionate about science and medicine and determined to understand how cells are transformed into tumors. We want to contribute to the fight to eradicate cancer by making impactful discoveries and training the next generation of scientists. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611705720668-8W9NHVJT98LFOHVUEFYM/image001.jpg MOSCAT and DIAZ-MECO LABs (Copy) - JOIN US We are Weill Cornell Medicine investigators located in the Weiss Building at the Rockefeller University Campus. We invite scientists of all stages (post-docs, graduate students, clinical fellows, undergraduate students, research associates) to join our team and contribute with exciting discoveries to help cure cancer. Join the fight! https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611875604732-MOEQTOOM7NOOD0ALNSHF/Publications.jpg MOSCAT and DIAZ-MECO LABs (Copy) - Publications We aim to disseminate our findings in high-impact publications https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611873495655-UQF96ASTQKRKR6OBE2B5/symposium2020_1.png MOSCAT and DIAZ-MECO LABs (Copy) - Research Areas The goal of our laboratories is to unravel the molecular and cellular mechanisms of cancer, creating synergies between the two labs to find common and specific vulnerabilities in each type of tumor. Only by understanding the enemy can we beat it! https://www.moscatdiazmecolab.org/test-from-support daily 0.75 2022-06-08 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611690970349-PXSNEE2CXR29NG5JEIEN/Kasashima2020.jpg test from support - Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population Kasashima H, Duran A, Martinez-Ordoñez A, Nakanishi Y, Kinoshita H, Linares JF, Reina-Campos M, Kudo Y, L'Hermitte A, Yashiro M, Ohira M, Bao F, Tauriello DVF, Batlle E, Diaz-Meco MT, Moscat J. Dev Cell. 2021 Jan 11;56(1):95-110.e10. doi: 10.1016/j.devcel.2020.10.014. Epub 2020 Nov 17. PMID: 33207226 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611697791277-VLPHETGIV15X7GVRCWZ5/Llado2015.jpg test from support - Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Llado V, Nakanishi Y, Duran A, Reina-Campos M, Shelton PM, Linares JF, Yajima T, Campos A, Aza-Blanc P, Leitges M, Diaz-Meco MT, Moscat J. Cell Rep. 2015 Feb 10;10(5):740-754. doi: 10.1016/j.celrep.2015.01.007. Epub 2015 Feb 5. PMID:25660024 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611697758636-WZD0WHE37K7KQCXW2UV5/Linares2015.jpg test from support - Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade. Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J, Diaz-Meco MT. Cell Rep. 2015 Aug 25;12(8):1339-52. doi: 10.1016/j.celrep.2015.07.045. Epub 2015 Aug 13. PMID:26279575 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/dacec581-c35f-450e-9315-7ead3b82dd70/Lactate_Figure_Graphical_v3.png test from support - The lactate-NAD + axis activates cancer-associated fibroblasts by downregulating p62 Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo H, Elemento O, Martin L, Cordes T, Thompson T, Metallo C, Moscat J, Diaz-Meco MT. Cell Rep. 2022 May 10, 39, 110792. doi: 10.1016/j.celrep.2022.110792. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611697406348-ZMTQW8QPLSZ0MSKP6XEE/Nakanishi2016.jpg test from support - Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι. Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J. Cell Rep. 2016 Sep 20;16(12):3297-3310. doi: 10.1016/j.celrep.2016.08.054. PMID:27653691 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611692496888-OWGAIAMD5WX02YVU3J3A/Nakanishi2018.jpg test from support - Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J. Immunity. 2018 Dec 18;49(6):1132-1147.e7. doi: 10.1016/j.immuni.2018.09.013. Epub 2018 Dec 11. PMID:30552022 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611692563775-KQ9WVKKWQOMOPGM977T6/Kudo2020.jpg test from support - PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. Cancer Cell. 2020 Aug 10;38(2):247-262.e11. doi: 10.1016/j.ccell.2020.05.018. Epub 2020 Jun 25. PMID: 32589943 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1621470028749-7TS7DY7O9OSGIK8Z99JX/41467_2021_23085_Fig9_HTML.jpg test from support - NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ Huang J, Linares JF, Duran A, Xia W, Saltiel AR, Müller TD, Diaz-Meco MT, Moscat J. Nat Commun. 2021 May 17;12(1):2876. doi: 10.1038/s41467-021-23085-0. PMID: 34001883 https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611695212836-8EX43SMQU9ACUZ6BWV0J/Duran2016.jpg test from support - p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. Cancer Cell. 2016 Oct 10;30(4):595-609. doi: 10.1016/j.ccell.2016.09.004. PMID:27728806 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611698299216-W70Q6B7CS6J7D42MXIHC/Hernandez2014.jpg test from support - A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J. Cell Metab. 2014 Sep 2;20(3):499-511. doi: 10.1016/j.cmet.2014.06.008. Epub 2014 Jul 17. PMID:25043814 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611698322765-HGPOCLOO1Y31CSRLTM2K/Valencia2014.jpg test from support - Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Valencia T, Kim JY, Abu-Baker S, Moscat-Pardos J, Ahn CS, Reina-Campos M, Duran A, Castilla EA, Metallo CM, Diaz-Meco MT, Moscat J. Cancer Cell. 2014 Jul 14;26(1):121-135. doi: 10.1016/j.ccr.2014.05.004. Epub 2014 Jul 4. PMID:25002027 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611689113375-28M2P9X15GXJCPQVG01V/Sheelton2018.jpg test from support - The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer. Shelton PM, Duran A, Nakanishi Y, Reina-Campos M, Kasashima H, Llado V, Ma L, Campos A, García-Olmo D, García-Arranz M, García-Olmo DC, Olmedillas-López S, Caceres JF, Diaz-Meco MT, Moscat J. Cell Rep. 2018 Apr 24;23(4):1178-1191. doi: 10.1016/j.celrep.2018.03.118. PMID:29694894 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611689041523-Z31TVDN4W7CU81OLR471/Huang2018.jpg test from support - Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor. Huang J, Duran A, Reina-Campos M, Valencia T, Castilla EA, Müller TD, Tschöp MH, Moscat J, Diaz-Meco MT. Cancer Cell. 2018 Apr 9;33(4):770-784.e6. doi: 10.1016/j.ccell.2018.03.001. PMID:29634950 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1632408776164-9NWTLYXI3G6KHG881WAZ/LINARES2021_graphical.jpeg test from support - PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis Linares JF, Zhang X, Martinez-Ordoñez A, Duran A, Kinoshita H, Kasashima H, Nakanishi N, Nakanishi Y, Carelli R, Cappelli L, Arias E, Yashiro M, Ohira M, Patel S, Inghirami G, Loda M, Cuervo AM, Diaz-Meco MT, Moscat J. Molecular Cell. 2021 November 4, 81, 1–18. doi.org/10.1016/j.molcel.2021.08.039ll https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611690778084-OFZLVE0T5I64RFYDQAUG/Linares2017.jpg test from support - ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PMID:28988820 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611692448130-JHJUS8AZSW4K24NV9B8F/Reina2019.jpg test from support - Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer Reina-Campos M, Linares JF, Duran A, Cordes T, L'Hermitte A, Badur MG, Bhangoo MS, Thorson PK, Richards A, Rooslid T, Garcia-Olmo DC, Nam-Cha SY, Salinas-Sanchez AS, Eng K, Beltran H, Scott DA, Metallo CM, Moscat J, Diaz-Meco MT. Cancer Cell. 2019 Mar 18;35(3):385-400.e9. doi: 10.1016/j.ccell.2019.01.018. Epub 2019 Feb 28. PMID:30827887 Free PMC article. https://images.squarespace-cdn.com/content/v1/60031dffe8c063189b666338/1611698342208-JA07Q0ZQUGO08ZXBSNV1/Ma2012.jpg test from support - Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J. Cell. 2013 Jan 31;152(3):599-611. doi: 10.1016/j.cell.2012.12.028. PMID:23374352 Free PMC article. https://www.moscatdiazmecolab.org/hot-off-the-press daily 0.75 2025-01-15